International trends in DM education

International Trends in Immunity

Tyrosine kinase inhibitors (TKIs) have dramatically improved the outcome of chronic myeloid leukemia (CML). Even though TKI therapy does not necessarily eliminate all leukemic cells, a small proportion of CML patients is able to discontinue the treatment successfully and be considered cured. Besides inhibiting the actual target BCR-ABL1 kinase in leukemic cells, TKIs inhibit several off-target ...

International Trends in Immunity

IL-15 is a member of the family of IL-2 cytokines. This family of cytokines activates signaling pathways leading to cellular activation, proliferation and survival. IL-15 exhibits broad activity and induces the differentiation and proliferation of NK, T and B cells. Furthermore, IL-15 protects T-effector cells from the action of T Regulatory cells and reverses tolerance to tumor associated anti...

International Trends in Immunity

5 Abstract— Allergies, asthma and autism have reached epidemic proportions, but the reason(s) why remain elusive. Recent evidence indicztes that mitochondria, commonly known for their cellular energy production, undergo fission and translocation to the cell surface where they secrete some of their components extracellularly. These include DNA and ATP, which are misconstrued by the body as “inna...

International Trends in Immunity

RIMARY immune deficiencies are genetic diseases caused by more than 200 single mutations. Each one of these mutations may/will affect the function of a cell activation pathway, a single cell population or a defined subset in innate or adaptive immunity.[1,2] Patients with secondary immunodeficiencies are a heterogenous group[3], comprising different disease entities: patients with HIV, patients...

Trends in International Migration